Carlo L Balduini Selected Research

Thrombopoietin (c-mpl Ligand)

1/2020	Eltrombopag for the treatment of inherited thrombocytopenias: a phase II clinical trial.
1/2019	EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis.
11/2018	Clinic, pathogenic mechanisms and drug testing of two inherited thrombocytopenias, ANKRD26-related Thrombocytopenia and MYH9-related diseases.
1/2018	Thrombopoietin mutation in congenital amegakaryocytic thrombocytopenia treatable with romiplostim.
12/2016	Revealing eltrombopag's promotion of human megakaryopoiesis through AKT/ERK-dependent pathway activation.
1/2013	High doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes.
7/2011	Recent advances in the understanding and management of MYH9-related inherited thrombocytopenias.
6/2011	Mutations in ANKRD26 are responsible for a frequent form of inherited thrombocytopenia: analysis of 78 patients from 21 families.
12/2010	Eltrombopag for the treatment of the inherited thrombocytopenia deriving from MYH9 mutations.
12/2007	Thrombopoietin is not uniquely responsible for thrombocytosis in inflammatory disorders.

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Carlo L Balduini Research Topics

Disease

25	Thrombocytopenia (Thrombopenia) 01/2021 - 08/2002
13	MYH9-Related Disorders 02/2014 - 02/2002
12	Hemorrhage 01/2022 - 05/2006
5	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 12/2016 - 09/2007
2	Bone Marrow Failure Disorders 01/2018 - 09/2007
2	Congenital amegakaryocytic thrombocytopenia 01/2018 - 09/2007
2	Neoplasms (Cancer) 01/2018 - 02/2013
2	Bernard-Soulier Syndrome (Giant Platelet Syndrome) 09/2014 - 03/2011
2	Thrombosis (Thrombus) 04/2012 - 08/2011
2	acquired Thrombotic thrombocytopenic purpura 08/2011 - 06/2010
2	Thrombotic Thrombocytopenic Purpura 08/2011 - 06/2010
2	Cataract (Cataracts) 11/2005 - 06/2004
2	Deafness (Deaf Mutism) 11/2005 - 06/2004
2	Glomerulonephritis 11/2005 - 01/2003
2	Renal Insufficiency (Renal Failure) 06/2004 - 01/2003
1	Primary Myelofibrosis (Myelosclerosis) 01/2019
1	Hyperplasia 01/2019
1	Splenomegaly 01/2019
1	Fibrosis (Cirrhosis) 01/2019
1	Wounds and Injuries (Trauma) 11/2018
1	Hematologic Neoplasms (Hematological Malignancy) 01/2018
1	Anemia 01/2018
1	Infections 01/2018
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2018
1	Liver Diseases (Liver Disease) 01/2018
1	Lung Diseases (Lung Disease) 01/2018
1	Aplastic Anemia (Anemia, Hypoplastic) 12/2016
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 12/2016
1	Epistaxis (Nosebleed) 11/2015
1	Telangiectasis (Telangiectasia) 11/2015
1	Neutropenia 02/2013
1	Gastritis 02/2013
1	Inborn Genetic Diseases (Disease, Hereditary) 02/2013
1	Cytopenia 02/2013
1	Hypertension (High Blood Pressure) 04/2012
1	Obesity 04/2012
1	Thrombotic Microangiopathies 08/2011
1	Hemolytic Anemia 08/2011
1	Thrombasthenia (Glanzmann Thrombasthenia) 05/2009
1	Myeloproliferative Disorders (Myeloproliferative Disorder) 03/2009
1	Thrombocytosis (Thrombocythemia) 12/2007
1	Pancytopenia 09/2007

Drug/Important Bio-Agent (IBA)

11	Thrombopoietin (c-mpl Ligand)IBA 01/2020 - 09/2007
10	Nonmuscle Myosin Type IIAIBA 01/2013 - 04/2002
5	eltrombopag FDA Link 01/2020 - 12/2010
5	Myosin Heavy Chains (Myosin Heavy Chain)IBA 02/2014 - 02/2002
3	Pharmaceutical PreparationsIBA 01/2021 - 12/2016
3	romiplostim FDA Link 01/2019 - 01/2013
3	von Willebrand FactorIBA 09/2014 - 05/2006
2	Hemostatics (Antihemorrhagics)IBA 01/2021 - 11/2018
2	Interleukin-6 (Interleukin 6)IBA 01/2019 - 12/2007
2	Protein Isoforms (Isoforms)IBA 01/2019 - 06/2004
2	Peptides (Polypeptides)IBA 12/2016 - 07/2011
2	Inosine Triphosphate (ITP)IBA 07/2013 - 01/2013
2	5' Untranslated Regions (5' UTR)IBA 02/2013 - 01/2011
2	Collagen Type I (Type I Collagen)IBA 10/2011 - 07/2009
2	thiamine triphosphorate (TTP)IBA 08/2011 - 06/2010
1	convulxinIBA 01/2019
1	human extra domain A fibronectinIBA 01/2019
1	CollagenIBA 01/2019
1	Fibronectins (Fibronectin)IBA 01/2019
1	Hemoglobins (Hemoglobin)IBA 01/2018
1	4,5,6,7- tetrahydroisoxazolo(4,5- c)pyridin- 3- ol (THPO)IBA 01/2018
1	Fibrinogen (Factor I)FDA Link 11/2016
1	Thalidomide (Thalomid)FDA Link 11/2015
1	ActininIBA 01/2015
1	DiamondIBA 02/2013
1	Proteins (Proteins, Gene)FDA Link 02/2013
1	Proteasome Endopeptidase Complex (Proteasome)IBA 02/2013
1	UbiquitinIBA 02/2013
1	Dronabinol (THC)FDA LinkGeneric 10/2012
1	Transcription Factors (Transcription Factor)IBA 10/2012
1	CholesterolIBA 04/2012
1	HDL CholesterolIBA 04/2012
1	AutoantibodiesIBA 08/2011
1	Metalloproteases (Metalloproteinases)IBA 08/2011
1	ThrombospondinsIBA 08/2011
1	DisintegrinsIBA 08/2011
1	Investigational DrugsIBA 08/2011
1	Thrombopoietin ReceptorsIBA 12/2010
1	Methylprednisolone FDA LinkGeneric 06/2010
1	Platelet Glycoprotein GPIIb-IIIa ComplexIBA 05/2009
1	IntegrinsIBA 05/2009
1	BuffersIBA 03/2009
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 12/2007
1	Hormones (Hormone)IBA 12/2007
1	CytokinesIBA 09/2007
1	Biological ProductsIBA 09/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2007
1	InterferonsIBA 09/2007

Therapy/Procedure

8	Therapeutics 01/2022 - 08/2002
2	Platelet Transfusion (Blood Platelet Transfusions) 01/2020 - 12/2010
1	Hematopoietic Stem Cell Transplantation 01/2018
1	Length of Stay 01/2018
1	Minimally Invasive Surgical Procedures 11/2015
1	Precision Medicine 02/2015
1	Hysterectomy 08/2014
1	Blood Transfusion (Blood Transfusions) 08/2014
1	Plasma Exchange 06/2010
1	Transjugular Intrahepatic Portasystemic Shunt 07/2009